Lymphocyte Activation

There has recently been tremendous progress in the field of signal transduction in lymphocytes. This volume provides a review of the field of lymphocyte activation. Authored by leading experts, the chapters include material on the structure of the T-cell and B-cell antigen receptors and the high-affinity receptor for IgE. The tyrosine kinases and phosphatases implicated in lymphocyte activation are described in great detail. Biochemical pathways that carry information from receptor to nucleus are also discussed. In addition to receptors that bind antigen, lymphokine and costimulatory receptors are surveyed. Reviewing the latest insights into lymphocyte signal transduction, this book should be a valuable aid to immunologists, biochemists and physicians with an interest in this area.