Integrin-ligand Interaction

The fate of cells is largely controled by the extracellular matrix. Cells recognize matrix constituents via integrins and they and their respective matrix ligands, as well as the subsequent signal transduction pathways and their influence on cell adhesion, migration and morphology, are the main subjects of this book. It emphasizes the importance of the three-dimensional structure and the conformation of the intrgrin recognition sites within the ligands.